Microbial Transformation of Prochiral Ketones Using Rhizopus arrhizus

被引:0
|
作者
Salokhe, Prabha R. [1 ]
Salunkhe, Rajeshri S. [1 ]
机构
[1] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India
关键词
Biotransformations; Transformation; Prochiral ketones; Rhizopus arrhizus; Bioreduction; Carbinols; ENANTIOMER; REDUCTION;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The various species Of Rhizopus arrhizus have been used tor microbial transformations of p-chloro, p-methyl and p-methoxy propiophenone to synthesize corresponding enantiomerically pure (S) alcohols in 7090 % ee. In a screening of various species of Rhizopus arrhizus for enantioselective reduction of propiophenone derivatives,. Rhizopus arrhizus NCIM-878 showed high activity for reduction of above prochiral ketones and it efficiently hydrolyzes the racemic acetate of p-methoxy propiophenone to corresponding (R) alcohol.
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页码:4333 / 4338
页数:6
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