Serum cholesterol levels preceding to suicide death in Japanese workers: a nested case-control study

被引：5

作者：

Chen, Sanmei ^{[1
]}

Mizoue, Tetsuya ^{[1
]}

Hu, Huanhuan ^{[1
]}

Kuwahara, Keisuke ^{[1
,2
]}

Honda, Toru ^{[3
]}

Yamamoto, Shuichiro ^{[3
]}

Nakagawa, Tohru ^{[3
]}

Miyamoto, Toshiaki ^{[4
]}

Okazaki, Hiroko ^{[5
]}

Shimizu, Makiko ^{[13
]}

Murakami, Taizo ^{[13
]}

Eguchi, Masafumi ^{[6
]}

Kochi, Takeshi ^{[6
]}

Yamamoto, Makoto ^{[7
]}

Ogasawara, Takayuki ^{[14
]}

Sasaki, Naoko ^{[14
]}

Uehara, Akihiko ^{[8
]}

Imai, Teppei ^{[9
]}

Nishihara, Akiko ^{[10
]}

Hori, Ai ^{[11
]}

Nagahama, Satsue ^{[12
]}

Tomita, Kentaro ^{[1
]}

Konishi, Maki ^{[1
]}

Kabe, Isamu ^{[6
]}

Dohi, Seitaro ^{[5
]}

机构：

[1] Natl Ctr Global Hlth & Med, Dept Epidemiol & Prevent, Tokyo, Japan

[2] Teikyo Univ, Grad Sch Publ Hlth, Tokyo, Japan

[3] Hitachi Ltd, Ibaraki, Japan

[4] Nippon Steel & Sumitomo Met Corp Kimitsu Works, Chiba, Japan

[5] Mitsui Chem Inc, Tokyo, Japan

[6] Furukawa Elect Corp Ltd, Tokyo, Japan

[7] Yamaha Corp, Shizuoka, Japan

[8] Seijinkai Shizunai Hosp, Shinhidaka, Hokkaido, Japan

[9] Azbil Corp, Tokyo, Japan

[10] Univ Tsukuba, Dept Global Publ Hlth, Ibaraki, Japan

[11] All Japan Labour Welf Fdn, Tokyo, Japan

[12] Mitsubishi Plast Inc, Tokyo, Japan

[13] Mizue Med Clin, Keihin Occupat Hlth Ctr, Tokyo, Kanagawa, Japan

[14] Mitsubishi Fuso Truck & Bus Corp, Kawasaki, Kanagawa, Japan

来源：

ACTA NEUROPSYCHIATRICA | 2019年 / 31卷 / 05期

基金：

日本学术振兴会;

关键词：

suicide; cholesterol; nested case-control study; working population; RISK-FACTORS; LIPID LEVELS; MORTALITY; MEN; COHORT;

D O I：

10.1017/neu.2019.26

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: To investigate the association between suicide death and serum cholesterol levels as measured at times close to suicide death. Methods: We conducted a nested case-control study of 41 cases of suicide deaths and 205 matched controls with serum total cholesterol (TC) levels till 3 years before suicide death in a large cohort of Japanese workers. Results: Individuals in the lowest versus highest tertile/predefined category of TC in a Japanese working population had a three- to four-fold greater risk of suicide death. Each 10 mg/dl decrement of average TC was associated with an 18% increased chance of suicide death (95% confidence interval, 2-35%). Similar results were found for TC levels at each year. Conclusion: These results suggest that a low serum TC level in recent past is associated with an increased risk of suicide death.

引用

页码：266 / 269

页数：4

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