A Fluorescent Probe for Hydrogen Peroxide in Vivo Based on the Modulation of Intramolecular Charge Transfer

被引：91

作者：

Chen, Yuzhi ^{[1
]}

Shi, Xiaomin ^{[3
]}

Lu, Zhengliang ^{[3
]}

Wang, Xuefei ^{[4
]}

Wang, Zhuo ^{[1
,2
]}

机构：

[1] Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, State Key Lab Chem Resource Engn, Coll Sci, Beijing 100029, Peoples R China

[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[3] Univ Jinan, Sch Chem & Chem Engn, Key Lab Chem Sensing & Anal Univ Shandong, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China

[4] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2017年 / 89卷 / 10期

关键词：

LIVING CELLS; SENSITIVE DETECTION; SELECTIVE DETECTION; FAST-RESPONSE; MITOCHONDRIA; PEROXYNITRITE; FLUORIDE; DESIGN; SENSOR; H2O2;

D O I：

10.1021/acs.analchem.6b04810

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Endogenous hydrogen peroxide in vivo is related to many diseases, including cancer, diabetes, cardiovascular disease, and neurodegenerative disorders. Although many probes for detection of 11202 have been explored, rapid response probes are still expected for in vivo application. Here, a new probe (PAM-BN-PB) was designed based on an intramolecular charge transfer (ICT) process with three parts: phenanthroimidazole, benzonitrile, and phenyl boronate. By modulation ICT process of PAM-BN-PB, H2O2 in solution systems can be detected with good selectivity. The exogenous and endogenous H2O2 in normal living cells, ischemia-reperfusion injury cells, and animals all can be imaged by PAM-BN-PB.

引用

页码：5278 / 5284

页数：7

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