A fluorescent hydrogen peroxide probe based on a 'click' modified coumarin fluorophore

被引：56
|
作者：
Du, Lupei Y. [1 ,2 ,3 ]
Ni, Nanting Y. [1 ,2 ]
Li, Minyong [1 ,2 ,3 ]
Wang, Binghe [1 ,2 ]
机构：
[1] Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA
[2] Georgia State Univ, Ctr Biotechnol & Drug Design, Atlanta, GA 30302 USA
[3] Shandong Univ, Sch Pharm, Jinan 250012, Shandong, Peoples R China
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 08期
关键词：
Hydrogen peroxide; Reactive oxygen species (ROS); Coumarin; Click chemistry; Fluorescence; ELECTROPHILIC DISPLACEMENT-REACTIONS; LIGATION; DESIGN; EVIL; H2O2;
D O I：
10.1016/j.tetlet.2009.12.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein a water-soluble 'click' modified coumarin-based fluorescent probe for hydrogen peroxide is reported. This probe shows significant intensity increases (up to fivefold) in near-green fluorescence upon reaction with hydrogen peroxide, and good selectivity over other reactive oxygen species. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1152 / 1154
页数：3
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