A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells

被引：59
|
作者：
He, Liang [1 ,2 ]
Zhang, Ming-Fang [2 ]
Pan, Zheng-Yin [2 ]
Wang, Kang-Nan [2 ]
Zhao, Zi-Jian [2 ]
Li, Yi [3 ]
Mao, Zong-Wan [1 ,2 ]
机构：
[1] South China Agr Univ, Coll Mat & Energy, Dept Appl Chem, Guangzhou 510642, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China
[3] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Minist Educ, Key Lab Theoret Organ Chem & Funct Mol, Xiangtan 411201, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 70期
基金：
中国国家自然科学基金;
关键词：
THERAPY; COMPLEXES; EFFICIENT; PHOTOSENSITIZER; NANOPARTICLES; HYPOXIA;
D O I：
10.1039/c9cc04871e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize O-1(2) generation, causing dual-mode (oxygen-independent and oxygen-dependent) photodynamic damage in mitochondria and killing cancer cells effectively even under hypoxic conditions.
引用
收藏
页码：10472 / 10475
页数：4
相关论文
共 43 条
  • [41] Multifunctional lymph-targeted platform based on Mn@mSiO2 nanocomposites: Combining PFOB for dual-mode imaging and DOX for cancer diagnose and treatment
    Tian Liu
    Guangyu Wu
    Jiejun Cheng
    Qing Lu
    Yanjie Yao
    Zhenjing Liu
    Dongchen Zhu
    Juan Zhou
    Jianrong Xu
    Jun Zhu
    Dannong He
    Nano Research, 2016, 9 : 473 - 489
  • [42] A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells
    Jing, Shaozhen
    Song, Ying-Qi
    Liu, Jingqi
    Zhao, Chen
    Wang, Ling
    Chan, Daniel Shiu-Hin
    Wong, Chun-Yuen
    Lee, Simon Ming-Yuen
    Wang, Jing
    Leung, Chung-Hang
    Wang, Wanhe
    SENSORS AND ACTUATORS B-CHEMICAL, 2024, 418
  • [43] Facile preparation of hyaluronic acid-modified Fe3O4@Mn3O4 nanocomposites for targeted T1/T2 dual-mode MR imaging of cancer cells
    Li, Jingchao
    Hu, Yong
    Sun, Wenjie
    Luo, Yu
    Shi, Xiangyang
    Shen, Mingwu
    RSC ADVANCES, 2016, 6 (42): : 35295 - 35304
12345