A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells

被引：59
|
作者：
He, Liang [1 ,2 ]
Zhang, Ming-Fang [2 ]
Pan, Zheng-Yin [2 ]
Wang, Kang-Nan [2 ]
Zhao, Zi-Jian [2 ]
Li, Yi [3 ]
Mao, Zong-Wan [1 ,2 ]
机构：
[1] South China Agr Univ, Coll Mat & Energy, Dept Appl Chem, Guangzhou 510642, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China
[3] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Minist Educ, Key Lab Theoret Organ Chem & Funct Mol, Xiangtan 411201, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 70期
基金：
中国国家自然科学基金;
关键词：
THERAPY; COMPLEXES; EFFICIENT; PHOTOSENSITIZER; NANOPARTICLES; HYPOXIA;
D O I：
10.1039/c9cc04871e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize O-1(2) generation, causing dual-mode (oxygen-independent and oxygen-dependent) photodynamic damage in mitochondria and killing cancer cells effectively even under hypoxic conditions.
引用
收藏
页码：10472 / 10475
页数：4
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