A new triterpene with antinociceptive activity from Maytenus robusta

被引：24

作者：

Niero, Rivaldo ^{[1
]}

Mafra, Ana P.

Lenzi, Ana C.

Cechinel-Filho, Valdir

Tischer, Cesar A.

Malheiros, Angela

De Souza, Marcia M.

Yunes, Rosendo A.

Delle Monache, Franco

机构：

[1] Univ Vale Itajai, NIQFAR CCS, BR-88302202 Itajai, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Rome, Dipartimento Chim & Tecnol Sostanze Biol Att, I-00185 Rome, Italy

来源：

NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 14期

关键词：

Maytenus robusta; Friedelanes; 3,15-dioxo-21 alpha-hydroxy friedelane; analgesic activity;

D O I：

10.1080/14786410601101951

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new triterpene 3,15-dioxo-21 alpha-hydroxy friedelane has been isolated from methanol extract of Maytenus robusta and its structure elucidated on the basis of spectral analysis. Stigmasterol, friedelin, friedelanol and 3,15-dioxo friedelane were also obtained. 3,15-dioxo-21 alpha-hydroxy friedelane was analyzed against the writhing test in mice and exhibited potent dose-dependent effects with an ID50 value of 12.5+/-2.1 mu mol kg(-1) and a maximal inhibition of 85.90%. It was about 10-fold more active than aspirin and paracetamol, used as reference drugs.

引用

页码：1315 / 1320

页数：6

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