A new triterpene with antinociceptive activity from Maytenus robusta

被引：24
|
作者：
Niero, Rivaldo [1 ]
Mafra, Ana P.
Lenzi, Ana C.
Cechinel-Filho, Valdir
Tischer, Cesar A.
Malheiros, Angela
De Souza, Marcia M.
Yunes, Rosendo A.
Delle Monache, Franco
机构：
[1] Univ Vale Itajai, NIQFAR CCS, BR-88302202 Itajai, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
[3] Univ Rome, Dipartimento Chim & Tecnol Sostanze Biol Att, I-00185 Rome, Italy
来源：
NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 14期
关键词：
Maytenus robusta; Friedelanes; 3,15-dioxo-21 alpha-hydroxy friedelane; analgesic activity;
D O I：
10.1080/14786410601101951
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new triterpene 3,15-dioxo-21 alpha-hydroxy friedelane has been isolated from methanol extract of Maytenus robusta and its structure elucidated on the basis of spectral analysis. Stigmasterol, friedelin, friedelanol and 3,15-dioxo friedelane were also obtained. 3,15-dioxo-21 alpha-hydroxy friedelane was analyzed against the writhing test in mice and exhibited potent dose-dependent effects with an ID50 value of 12.5+/-2.1 mu mol kg(-1) and a maximal inhibition of 85.90%. It was about 10-fold more active than aspirin and paracetamol, used as reference drugs.
引用
收藏
页码：1315 / 1320
页数：6
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