The preparation of dopaminergic agonist [5,8-3H] (±)2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene at high specific activity

被引：6

作者：

Orphanos, D ^{[1
]}

Filer, CN ^{[1
]}

机构：

[1] Perkin Elmer Life Sci Inc, Boston, MA 02118 USA

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2002年 / 254卷 / 01期

关键词：

HPLC; Dopamine; Inorganic Chemistry; Tritium; Receptor Binding;

D O I：

10.1023/A:1020838925044

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The rigid dopamine analogue (+/-) 6,7-ADTN was originally synthesized to probe the geometrical constraints of the dopamine receptor family and [H-3] (+/-) 6,7-ADTN was required for receptor binding assay. The radioligands was prepared by means of catalytic tritium dehalogenation of a suitable dibromo precursor and characterized by HPLC and tritium NMR. It has proven very useful as a tool to study dopaminergic receptors.

引用

页码：223 / 224

页数：2

共 50 条

[41] DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE, .2. SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF N-SUBSTITUTED TRANS-2-AMINO-3-HYDROXY-5,8-DIMETHOXY-1,2,3,4-TETRAHYDRONAPHTHALENES
DANTCHEV, D
CHRISTOVA, K
STANEVA, D
RAINOVA, L
TSCHAKAROVA, L
ARCHIV DER PHARMAZIE, 1977, 310 (05) : 369 - 379
[42] ANALYSIS OF SYMPATHOMIMETIC ACTIVITY OF 6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISO-QUINOLINE (TIQ)
SIMPSON, LL
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1975, 192 (02): : 365 - 371
[43] COMPARISON OF EFFECTS OF 2-AMINO-6,7-DIHYDROXY-1,2,3,4-TETRAHYDRONAPTHALENE(ADTN) AND APOMORPHINE(APO) ON DOPAMINE-SENSITIVE CILIARY ACTIVITY AND CAMP LEVELS IN BIVALVE MOLLUSCAN GILL
MALANGA, CJ
ODONNELL, JP
POLL, KA
PHARMACOLOGIST, 1977, 19 (02): : 204 - 204
[44] trans,trans,trans-2,3,5,8-tetrabromo-1,4-dihydroxy-1,2,3,4-tetrahydronaphthalene
Akkurt, M
Çelik, I
Erenler, R
Çakmak, O
Ersanli, CC
Büyükgüngör, O
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2004, 60 : O2096 - O2098
[45] Application of (2R,3R)-dihydroxy-1,2,3,4-tetrahydronaphthalene to asymmetric synthesis
Orsini, F
Rinaldi, S
TETRAHEDRON-ASYMMETRY, 1997, 8 (07) : 1039 - 1048
[46] BIOSYNTHESIS OF 3-CARBOXY-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE AND 1-METHYL-3-CARBOXY-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE IN A CALLUS-CULTURE OF STIZOLOBIUM-HASSJOO
OBATASASAMOTO, H
KOMAMINE, A
SAITO, K
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 1981, 36 (11-1): : 921 - 924
[47] CARDIOVASCULAR EFFECTS OF 2-(NN-DIMETHYL)AMINO-6,7-DIHYDROXY-1,2,3,4- TETRAHYDRONAPHTHALENE IN PITHED RATS - DIFFERENTIAL ANTAGONISM BY YOHIMBINE AND PRAZOSIN
HICKS, PE
CANNON, JG
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1980, 32 (11) : 786 - 788
[48] DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE .9. STRUCTURE-ACTIVITY-RELATIONSHIPS OF CIS-2-AMINO-5,8-DIMETHOXYTETRALIN-3-OLS AND TRANS-2-AMINO-5,8-DIMETHOXYTETRALIN-3-OLS AND SOME ANALOGS
CHRISTOVA, K
DANTCHEV, D
STANEVA, D
RAINOVA, L
ARCHIV DER PHARMAZIE, 1984, 317 (10) : 829 - 834
[49] INHIBITION OF TRYPTOPHAN-HYDROXYLASE BY (R)-1-METHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE AND (S)-1-METHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE (SALSOLINOLS)
OTA, M
DOSTERT, P
HAMANAKA, T
NAGATSU, T
NAOI, M
NEUROPHARMACOLOGY, 1992, 31 (04) : 337 - 341
[50] DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE .7. AROYL ESTERS OF CIS AND TRANS-2-DIMETHYLAMINO-3-HYDROXY-5,8-DIMETHOXY-1,2,3,4-TETRAHYDRONAPHTHALENES
CHRISTOVA, K
DANTSCHEV, D
RAINOVA, L
STANEVA, D
ARCHIV DER PHARMAZIE, 1982, 315 (09) : 797 - 801

← 1 2 3 4 5 →