The preparation of dopaminergic agonist [5,8-3H] (±)2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene at high specific activity

被引：6

作者：

Orphanos, D ^{[1
]}

Filer, CN ^{[1
]}

机构：

[1] Perkin Elmer Life Sci Inc, Boston, MA 02118 USA

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2002年 / 254卷 / 01期

关键词：

HPLC; Dopamine; Inorganic Chemistry; Tritium; Receptor Binding;

D O I：

10.1023/A:1020838925044

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The rigid dopamine analogue (+/-) 6,7-ADTN was originally synthesized to probe the geometrical constraints of the dopamine receptor family and [H-3] (+/-) 6,7-ADTN was required for receptor binding assay. The radioligands was prepared by means of catalytic tritium dehalogenation of a suitable dibromo precursor and characterized by HPLC and tritium NMR. It has proven very useful as a tool to study dopaminergic receptors.

引用

页码：223 / 224

页数：2

共 50 条

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