The preparation of dopaminergic agonist [5,8-3H] (±)2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene at high specific activity

被引：6
|
作者：
Orphanos, D [1 ]
Filer, CN [1 ]
机构：
[1] Perkin Elmer Life Sci Inc, Boston, MA 02118 USA
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2002年 / 254卷 / 01期
关键词：
HPLC; Dopamine; Inorganic Chemistry; Tritium; Receptor Binding;
D O I：
10.1023/A:1020838925044
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The rigid dopamine analogue (+/-) 6,7-ADTN was originally synthesized to probe the geometrical constraints of the dopamine receptor family and [H-3] (+/-) 6,7-ADTN was required for receptor binding assay. The radioligands was prepared by means of catalytic tritium dehalogenation of a suitable dibromo precursor and characterized by HPLC and tritium NMR. It has proven very useful as a tool to study dopaminergic receptors.
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收藏
页码：223 / 224
页数：2
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