Synthesis and biological properties of new glycosidic cationic lipids for DNA delivery

被引：24
|
作者：
Bessodes, M [1 ]
Dubertret, C [1 ]
Jaslin, G [1 ]
Scherman, D [1 ]
机构：
[1] CNRS, ENSCP, Lab Vectorol Mol & Cellulaire, UMR7001,Aventis Pharma Gencell, F-94403 Vitry Sur Seine, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(00)00251-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Lipidic glycosides with amino alkyl pendent groups were synthesized and evaluated for in vitro DNA transfection activity. The first representative of this new class of cationic lipids showed good gene delivery and low toxicity to HeLa and 3T3 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1393 / 1395
页数：3
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