Rational design of cationic lipids for siRNA delivery

被引：0
|
作者：
Sean C Semple
Akin Akinc
Jianxin Chen
Ammen P Sandhu
Barbara L Mui
Connie K Cho
Dinah W Y Sah
Derrick Stebbing
Erin J Crosley
Ed Yaworski
Ismail M Hafez
J Robert Dorkin
June Qin
Kieu Lam
Kallanthottathil G Rajeev
Kim F Wong
Lloyd B Jeffs
Lubomir Nechev
Merete L Eisenhardt
Muthusamy Jayaraman
Mikameh Kazem
Martin A Maier
Masuna Srinivasulu
Michael J Weinstein
Qingmin Chen
Rene Alvarez
Scott A Barros
Soma De
Sandra K Klimuk
Todd Borland
Verbena Kosovrasti
William L Cantley
Ying K Tam
Muthiah Manoharan
Marco A Ciufolini
Mark A Tracy
Antonin de Fougerolles
Ian MacLachlan
Pieter R Cullis
Thomas D Madden
Michael J Hope
机构：
[1] Tekmira Pharmaceuticals,Department of Biochemistry and Molecular Biology
[2] Burnaby,Department of Chemistry
[3] British Columbia,undefined
[4] Alnylam Pharmaceuticals,undefined
[5] Cambridge,undefined
[6] University of British Columbia,undefined
[7] University of British Columbia,undefined
[8] Present address: Alcana Technologies,undefined
[9] Vancouver,undefined
[10] British Columbia,undefined
[11] Canada.,undefined
来源：
Nature Biotechnology | 2010年 / 28卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Efficient siRNA delivery remains a key challenge to realizing the full potential of RNAi-based therapeutics. Semple et al. accomplish unprecedented potency for liposome-mediated siRNA delivery by applying rational design to refine an empirically identified cationic lipid widely regarded as the benchmark for use in lipid nanoparticles.
引用
收藏
页码：172 / 176
页数：4
相关论文
共 50 条
  • [1] Rational design of cationic lipids for siRNA delivery
    Semple, Sean C.
    Akinc, Akin
    Chen, Jianxin
    Sandhu, Ammen P.
    Mui, Barbara L.
    Cho, Connie K.
    Sah, Dinah W. Y.
    Stebbing, Derrick
    Crosley, Erin J.
    Yaworski, Ed
    Hafez, Ismail M.
    Dorkin, J. Robert
    Qin, June
    Lam, Kieu
    Rajeev, Kallanthottathil G.
    Wong, Kim F.
    Jeffs, Lloyd B.
    Nechev, Lubomir
    Eisenhardt, Merete L.
    Jayaraman, Muthusamy
    Kazem, Mikameh
    Maier, Martin A.
    Srinivasulu, Masuna
    Weinstein, Michael J.
    Chen, Qingmin
    Alvarez, Rene
    Barros, Scott A.
    De, Soma
    Klimuk, Sandra K.
    Borland, Todd
    Kosovrasti, Verbena
    Cantley, William L.
    Tam, Ying K.
    Manoharan, Muthiah
    Ciufolini, Marco A.
    Tracy, Mark A.
    de Fougerolles, Antonin
    MacLachlan, Ian
    Cullis, Pieter R.
    Madden, Thomas D.
    Hope, Michael J.
    NATURE BIOTECHNOLOGY, 2010, 28 (02) : 172 - U18
  • [2] Versatile cationic lipids for siRNA delivery
    Sparks, Jeff
    Slobodkin, Gregory
    Matar, Majed
    Congo, Richard
    Ulkoski, David
    Rea-Ramsey, Angela
    Pence, Casey
    Rice, Jennifer
    McClure, Diane
    Polach, Kevin J.
    Brunhoeber, Elaine
    Wilkinson, Leslie
    Wallace, Kirby
    Anwer, Khursheed
    Fewell, Jason G.
    JOURNAL OF CONTROLLED RELEASE, 2012, 158 (02) : 269 - 276
  • [3] Cationic lipids and polymers mediated vectors for delivery of siRNA
    Zhang, Shubiao
    Zhao, Budiao
    Jiang, Huiming
    Wang, Bing
    Ma, Baichao
    JOURNAL OF CONTROLLED RELEASE, 2007, 123 (01) : 1 - 10
  • [4] Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery
    Malamas, Anthony S.
    Gujrati, Maneesh
    Kummitha, China M.
    Xu, Rongzuo
    Lu, Zheng-Rong
    JOURNAL OF CONTROLLED RELEASE, 2013, 171 (03) : 296 - 307
  • [5] Optimized combination of cationic lipids and neutral helper lipids in cationic liposomes for siRNA delivery into the lung by intravenous injection of siRNA lipoplexes
    Hattori, Yoshiyuki
    Tamaki, Kyoko
    Ozaki, Kei-ichi
    Kawano, Kumi
    Onishi, Hiraku
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 52 : 1042 - 1050
  • [6] The design of cationic lipids for gene delivery
    Martin, B
    Sainlos, M
    Aissaoui, A
    Oudrhiri, N
    Hauchecorne, M
    Vigneron, JP
    Lehn, JM
    Lehn, P
    CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (03) : 375 - 394
  • [7] Novel Cationic Multivalent Lipids Show Improved Delivery of siRNA and DNA
    Bouxsein, Nathan F.
    Ewert, Kai K.
    McAllister, Christopher S.
    Evans, Heather M.
    Samuel, Charles E.
    Safinya, Cyrus R.
    MOLECULAR THERAPY, 2006, 13 : S71 - S72
  • [8] The development of tertiary amine cationic lipids for safe and efficient siRNA delivery
    Lin, Ziming
    Bao, Moxyel
    Yu, Zexuan
    Xue, Lingjing
    Ju, Caoyun
    Zhang, Can
    BIOMATERIALS SCIENCE, 2019, 7 (07) : 2777 - 2792
  • [9] Cationic Nucleoside Lipids Derived from Universal Bases: A Rational Approach for siRNA Transfection
    Ceballos, Claire
    Khiati, Salim
    Prata, Carla A. H.
    Zhang, Xiao-Xiang
    Giorgio, Suzanne
    Marsal, Philippe
    Grinstaff, Mark W.
    Barthelemy, Philippe
    Camplo, Michel
    BIOCONJUGATE CHEMISTRY, 2010, 21 (06) : 1062 - 1069
  • [10] Custom Synthesized Degradable Multivalent Cationic Lipids for Enhance Gene and siRNA Delivery
    Shirazi, Rahau S.
    Ewert, Kai K.
    Leal, Cecilia
    Bouxsein, Nathan F.
    Safinya, Cyrus R.
    MOLECULAR THERAPY, 2009, 17 : S49 - S50
12345