Rational design of cationic lipids for siRNA delivery

被引：0
|
作者：
Sean C Semple
Akin Akinc
Jianxin Chen
Ammen P Sandhu
Barbara L Mui
Connie K Cho
Dinah W Y Sah
Derrick Stebbing
Erin J Crosley
Ed Yaworski
Ismail M Hafez
J Robert Dorkin
June Qin
Kieu Lam
Kallanthottathil G Rajeev
Kim F Wong
Lloyd B Jeffs
Lubomir Nechev
Merete L Eisenhardt
Muthusamy Jayaraman
Mikameh Kazem
Martin A Maier
Masuna Srinivasulu
Michael J Weinstein
Qingmin Chen
Rene Alvarez
Scott A Barros
Soma De
Sandra K Klimuk
Todd Borland
Verbena Kosovrasti
William L Cantley
Ying K Tam
Muthiah Manoharan
Marco A Ciufolini
Mark A Tracy
Antonin de Fougerolles
Ian MacLachlan
Pieter R Cullis
Thomas D Madden
Michael J Hope
机构：
[1] Tekmira Pharmaceuticals,Department of Biochemistry and Molecular Biology
[2] Burnaby,Department of Chemistry
[3] British Columbia,undefined
[4] Alnylam Pharmaceuticals,undefined
[5] Cambridge,undefined
[6] University of British Columbia,undefined
[7] University of British Columbia,undefined
[8] Present address: Alcana Technologies,undefined
[9] Vancouver,undefined
[10] British Columbia,undefined
[11] Canada.,undefined
来源：
Nature Biotechnology | 2010年 / 28卷
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摘要：
Efficient siRNA delivery remains a key challenge to realizing the full potential of RNAi-based therapeutics. Semple et al. accomplish unprecedented potency for liposome-mediated siRNA delivery by applying rational design to refine an empirically identified cationic lipid widely regarded as the benchmark for use in lipid nanoparticles.
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页码：172 / 176
页数：4
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