A new chemical probe for the detection of the cancer-linked galectin-3

被引：47
|
作者：
Ballell, Lluis [1 ]
van Scherpenzeel, Monique [1 ]
Buchalova, Katerina [1 ]
Liskamp, Rob M. J. [1 ]
Pieters, Roland J. [1 ]
机构：
[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TB Utrecht, Netherlands
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 23期
关键词：
D O I：
10.1039/b611050a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chemical probe was developed for the detection of the emerging cancer marker galectin-3. The probe contains a benzophenone moiety which covalently attaches itself to the protein upon binding and irradiation. Introduction of a fluorescent label via 'click' chemistry allows the labelled proteins to be visualized in a gel. With the probe, selective visualization of galectin-3 in protein mixtures was shown and remarkably even in cell lysates.
引用
收藏
页码：4387 / 4394
页数：8
相关论文
共 50 条
  • [41] Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer
    Julie Ellerhorst
    Patricia Troncoso
    Xiao-Chun Xu
    Jack Lee
    Reuben Lotan
    Urological Research, 1999, 27 : 362 - 367
  • [42] Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis
    Jacob J. Swidorski
    Brett R. Beno
    Chunjian Liu
    David S. Yoon
    Kaushik Ghosh
    Harinath Sale
    Devang Shah
    Kriti Acharya
    Joseph Yanchunas
    Priyanka Haldar
    Narasimharaju Kalidindi
    Jinal K. Shukla
    Matthew Argentieri
    Bruce A. Ellsworth
    Dong Cheng
    Alicia Regueiro-Ren
    Medicinal Chemistry Research, 2023, 32 : 1453 - 1480
  • [43] Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis
    Swidorski, Jacob J.
    Beno, Brett R.
    Liu, Chunjian
    Yoon, David S.
    Ghosh, Kaushik
    Sale, Harinath
    Shah, Devang
    Acharya, Kriti
    Yanchunas, Joseph
    Haldar, Priyanka
    Kalidindi, Narasimharaju
    Shukla, Jinal K.
    Argentieri, Matthew
    Ellsworth, Bruce A.
    Cheng, Dong
    Regueiro-Ren, Alicia
    MEDICINAL CHEMISTRY RESEARCH, 2023, 32 (07) : 1453 - 1480
  • [44] Can cathepsin-D and galectin-3 be new inflammation biomarkers in detection of lysosomal diseases?
    Ergun, Pelin
    Kagnici, Mehtap
    Ucar, Sema Kalkan
    Coker, Mahmut
    Akcay, Yasemin Delen
    Sozmen, Eser Yildirim
    MOLECULAR GENETICS AND METABOLISM, 2015, 114 (02) : S42 - S42
  • [45] The Growing Galectin Network in Colon Cancer and Clinical Relevance of Cytoplasmic Galectin-3 Reactivity
    Dawson, Heather
    Andre, Sabine
    Karamitopoulou, Eva
    Zlobec, Inti
    Gabius, Hans-Joachim
    ANTICANCER RESEARCH, 2013, 33 (08) : 3053 - 3059
  • [46] Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer
    Ellerhorst, J
    Troncoso, P
    Xu, XC
    Lee, J
    Lotan, R
    UROLOGICAL RESEARCH, 1999, 27 (05): : 362 - 367
  • [47] Galectin-3 modulates glioblastomas (GBM) tumor microenvironment, and is linked to glioblastoma invasion
    Wesley, Umadevi V.
    Resad, Esat
    Clark, Paul
    Larrain, Carolina
    Kuo, John
    Dempsey, Robert J.
    CANCER RESEARCH, 2015, 75
  • [48] Circulating galectin-3 in the bloodstream: an emerging promoter of cancer metastasis
    Yu, Lu-Gang
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2010, 26 : S39 - S39
  • [49] Immunohistochemical analysis for galectin-3 and outcomes in medullary thyroid cancer
    Raia, S.
    Chiloiro, S.
    Giampietro, A.
    Lugli, F.
    Maratta, M. G.
    Rossi, E. D.
    de Marinis, L.
    Rufini, V
    Schinzari, G.
    Rindi, G.
    Pontecorvi, A.
    Bianchi, A.
    JOURNAL OF NEUROENDOCRINOLOGY, 2024, 36 : 169 - 169
  • [50] Molecular and functional aspects of Galectin-3 expression in thyroid cancer
    Bartolazzi, A
    Soddu, S
    Sciacchitano, S
    BIOMEDICINE & PHARMACOTHERAPY, 2004, 58 (08) : 475 - 475
12345