A new chemical probe for the detection of the cancer-linked galectin-3

被引：47

作者：

Ballell, Lluis ^{[1
]}

van Scherpenzeel, Monique ^{[1
]}

Buchalova, Katerina ^{[1
]}

Liskamp, Rob M. J. ^{[1
]}

Pieters, Roland J. ^{[1
]}

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TB Utrecht, Netherlands

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 23期

关键词：

D O I：

10.1039/b611050a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemical probe was developed for the detection of the emerging cancer marker galectin-3. The probe contains a benzophenone moiety which covalently attaches itself to the protein upon binding and irradiation. Introduction of a fluorescent label via 'click' chemistry allows the labelled proteins to be visualized in a gel. With the probe, selective visualization of galectin-3 in protein mixtures was shown and remarkably even in cell lysates.

引用

页码：4387 / 4394

页数：8

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