A new chemical probe for the detection of the cancer-linked galectin-3

被引：47
|
作者：
Ballell, Lluis [1 ]
van Scherpenzeel, Monique [1 ]
Buchalova, Katerina [1 ]
Liskamp, Rob M. J. [1 ]
Pieters, Roland J. [1 ]
机构：
[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TB Utrecht, Netherlands
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 23期
关键词：
D O I：
10.1039/b611050a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chemical probe was developed for the detection of the emerging cancer marker galectin-3. The probe contains a benzophenone moiety which covalently attaches itself to the protein upon binding and irradiation. Introduction of a fluorescent label via 'click' chemistry allows the labelled proteins to be visualized in a gel. With the probe, selective visualization of galectin-3 in protein mixtures was shown and remarkably even in cell lysates.
引用
收藏
页码：4387 / 4394
页数：8
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