Solid state investigation and characterization of the polymorphic and pseudopolymorphic forms of indapamide

被引：23
|
作者：
Ghugare, Pradeep [1 ,2 ,3 ]
Dongre, Vaijanath [3 ]
Karmuse, Pravin [2 ,3 ]
Rana, Ragnesh [2 ]
Singh, Dharmendra [2 ]
Kumar, Ashok [2 ]
Filmwala, Zoeb [1 ]
机构：
[1] St Xaviers Coll, Dept Chem, Nadkarni Sacasa Res Lab, Bombay 400001, Maharashtra, India
[2] Ipca Labs Ltd, Div Chem Res, Bombay 400067, Maharashtra, India
[3] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2010年 / 51卷 / 03期
关键词：
Indapamide; Polymorphs; Pseudopolymorphs; XRPD; Solid state characterization; PHARMACEUTICAL APPLICATIONS; CRYSTAL; SULFONAMIDES;
D O I：
10.1016/j.jpba.2009.09.003
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Solid state investigation and polymorphic screening of indapamide, a diuretic drug generally used for the treatment of hypertension was carried out. Substantial differences were obtained in the solid state properties of crystals confirming the existence of a polymorphic and three pseudopolymorphic forms of indapamide. Detailed methods of preparation of the polymorphs and pseudopolymorphs are described. X-ray powder diffraction (XRPD), diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were employed for the characterization of different crystalline forms of indapamide. The stoichiometric ratio of solvents associated with the drug molecules in the pseudopolymorphic forms were calculated using TGA, nuclear magnetic resonance (NMR) spectroscopy and headspace gas chromatographic (HS-GC) analysis. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：532 / 540
页数：9
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