Full spectroscopic characterization of two crystal pseudopolymorphic forms of the antiandrogen cortexolone 17α-propionate for topic application

被引：6

作者：

Ferraboschi, Patrizia ^{[1
]}

Sala, Maria Chiara ^{[2
]}

Stradi, Riccardo ^{[2
]}

Ragonesi, Laura ^{[3
]}

Gagliardi, Clarissa ^{[3
]}

Lanzarotti, Paolo ^{[3
]}

Ragg, Enzio M. ^{[4
]}

Mori, Matteo ^{[5
]}

Meneghetti, Fiorella ^{[5
]}

机构：

[1] Univ Milan, Dipartimento Biotecnol Med & Med Traslaz, Via C Saldini 50, I-20133 Milan, Italy

[2] SINCHEMIA Srl, Via Sansovino 23, I-20133 Milan, Italy

[3] Cosmo SpA, Via C Colombo 1, I-20020 Lainate, MI, Italy

[4] Univ Milan, Dipartimento Sci Alimenti Nutr & Ambiente, Via Celoria 2, I-20133 Milan, Italy

[5] Univ Milan, Dipartimento Sci Farmaceut, Via L Mangiagalli 25, I-20133 Milan, Italy

来源：

STEROIDS | 2017年 / 128卷

关键词：

Solvopolymorphism; Steroidal hormone; X-ray diffractometry; Solid-state NMR spectroscopy; SOLID-STATE NMR; TESTOSTERONE; ACNE; METABOLISM; REACTIVITY; ALOPECIA; SKIN;

D O I：

10.1016/j.steroids.2017.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cortexolone-17 alpha-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The single crystal structure of the monohydrated phase, CPW, compared with that of the anhydrous form CPIII, shows a markedly different solid state behavior. These latter pseudopolymorphic forms have also been fully characterized by spectroscopic methods.

引用

页码：95 / 104

页数：10