A CONVENIENT SYNTHETIC METHOD FOR FLUORINE-CONTAINING 4-ALKOXYDIHYDROBENZO[b][1,4]DIAZEPINOLS AND 3H-BENZO[b][1,4]DIAZEPINES BY THE REACTION OF β-TRIFLUOROACETYLKETENE ACETALS WITH 1,2-PHENYLENEDIAMINES

被引：7
|
作者：
Ota, Norio [1 ]
Okada, Etsuji [1 ]
Terai, Naoya [1 ]
Miyamura, Tomomi [1 ]
Shibata, Dai [1 ]
Sakata, Tsuneaki [2 ]
机构：
[1] Kobe Univ, Dept Sci & Chem Engn, Grad Sch Engn, Nada Ku, Kobe, Hyogo 6578501, Japan
[2] Kobe Univ, Dept Life Sci, Grad Sch Sci & Technol, Nada Ku, Kobe, Hyogo 6578501, Japan
来源：
HETEROCYCLES | 2009年 / 77卷 / 02期
关键词：
2,3-Dihydro-1H-benzo[b][1,4]diazepinol; 3H-Benzo[b][1,4]diazepine; Trifluoromethyl Group; Annulation; 1,2-Phenylenediamine; FACILE SYNTHESES; OXAZOLES;
D O I：
10.3987/COM-08-S(F)72
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
beta-Trifluoroacetylketene dialkyl acetals (3 and 5) reacted easily with various 1,2-phenylenediamines to give novel 4-alkoxy-2-trifluoromethyl-2,3-dihydro-1H-benzo[b][1,4]diazepinols (6 and 8) in moderate to high yields. Dehydration of 6 and 8 proceeded thermally under reduced pressure to afford the corresponding fluorine-containing 3H-benzo[b][1,4]diazepines (7 and 9).
引用
收藏
页码：983 / 990
页数：8
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