A CONVENIENT SYNTHETIC METHOD FOR FLUORINE-CONTAINING 4-ALKOXYDIHYDROBENZO[b][1,4]DIAZEPINOLS AND 3H-BENZO[b][1,4]DIAZEPINES BY THE REACTION OF β-TRIFLUOROACETYLKETENE ACETALS WITH 1,2-PHENYLENEDIAMINES

被引：7

作者：

Ota, Norio ^{[1
]}

Okada, Etsuji ^{[1
]}

Terai, Naoya ^{[1
]}

Miyamura, Tomomi ^{[1
]}

Shibata, Dai ^{[1
]}

Sakata, Tsuneaki ^{[2
]}

机构：

[1] Kobe Univ, Dept Sci & Chem Engn, Grad Sch Engn, Nada Ku, Kobe, Hyogo 6578501, Japan

[2] Kobe Univ, Dept Life Sci, Grad Sch Sci & Technol, Nada Ku, Kobe, Hyogo 6578501, Japan

来源：

HETEROCYCLES | 2009年 / 77卷 / 02期

关键词：

2,3-Dihydro-1H-benzo[b][1,4]diazepinol; 3H-Benzo[b][1,4]diazepine; Trifluoromethyl Group; Annulation; 1,2-Phenylenediamine; FACILE SYNTHESES; OXAZOLES;

D O I：

10.3987/COM-08-S(F)72

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Trifluoroacetylketene dialkyl acetals (3 and 5) reacted easily with various 1,2-phenylenediamines to give novel 4-alkoxy-2-trifluoromethyl-2,3-dihydro-1H-benzo[b][1,4]diazepinols (6 and 8) in moderate to high yields. Dehydration of 6 and 8 proceeded thermally under reduced pressure to afford the corresponding fluorine-containing 3H-benzo[b][1,4]diazepines (7 and 9).

引用

页码：983 / 990

页数：8

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