Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba

被引：48
|
作者：
Kang, Kyo Bin [1 ,2 ]
Ming, Gao [3 ]
Kim, Geum Jin [3 ]
Ha, Thi-Kim-Quy [1 ,2 ]
Choi, Hyukjae [3 ]
Oh, Won Keun [1 ,2 ]
Sung, Sang Hyun [1 ,2 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea
[3] Yeungnam Univ, Coll Pharm, Kyongsan 712749, Gyeongbuk, South Korea
来源：
PHYTOCHEMISTRY | 2015年 / 119卷
基金：
新加坡国家研究基金会;
关键词：
Ziziphus jujuba; Rhamnaceae; Cyclopeptide alkaloids; Jubanines; Antiviral; AMINO-ACIDS; PALIURUS-RAMOSSISIMUS; MASS-SPECTROMETRY; PEPTIDE ALKALOIDS; PLANT;
D O I：
10.1016/j.phytochem.2015.09.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Five Ib-type cyclopeptide alkaloids, jubanines F-J (1-5), and three known compounds, nummularine B (6), daechuine-S3 (7), and mucronine K (8) were isolated from the roots of Ziziphus jujuba. Their structures were fully characterized by spectroscopic analyses in combination with chemical derivatization. Compounds 1-3, and 6 were evaluated for their antiviral activity against the porcine epidemic diarrhea virus (PEDV). Compounds 2, 3, and 6 showed potent inhibitory effects on PEDV replication. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：90 / 95
页数：6
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