Cytotoxic Ceanothane- and Lupane-Type Triterpenoids from the Roots of Ziziphus jujuba

被引:32
|
作者
Kang, Kyo Bin
Kim, Jung Wha
Oh, Won Keun
Kim, Jinwoong
Sung, Sang Hyun [1 ]
机构
[1] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea
来源
JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 09期
基金
新加坡国家研究基金会;
关键词
ZIZYPHUS-JUJUBA; BETULINIC ACID; NORTRITERPENES; CONSTITUENTS; DERIVATIVES; CAMBODIANA; FRUITS; AGENTS; MILL;
D O I
10.1021/acs.jnatprod.6b00525
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Ziziphus jujuba, a plant in the family Rhamnaceae, is used in several Asian countries as a food and traditional medicine. Fifteen new ceanothane-type (1-15) and three new lupane-type triterpenoids (16-18) were isolated from the roots of Z. jujuba, as well, as 12 previously known triterpenoids (19-30). Their structures were elucidated by 1D and 2D NMR spectroscopic and HR mass spectrometric data analysis. Compounds 12 and 13 were found to possess a rare E-ring gamma-lactone structure, and 14 was assigned as the first 2,28-dinorlupane derivative isolated as a natural product. Twenty-five of the isolates were examined for cytotoxicity against human hepatocellular carcinoma HepG2 cells, and compounds 6-8, 14, 17, 23, 25, 29, and 30 showed cytotoxicity with IC50 values ranging from 1.9 to 5.9 mu M.
引用
收藏
页码:2364 / 2375
页数:12
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