Cyclopeptide Alkaloids from Ziziphus apetala

被引：20

作者：

Han, Jing ^{[1
,4
]}

Ji, Chang-Jiu ^{[1
,4
]}

He, Wen-Jun ^{[1
]}

Shen, Yu ^{[2
,4
]}

Leng, Ying ^{[2
]}

Xu, Wen-Yan ^{[1
]}

Fan, Jun-Ting ^{[1
]}

Zeng, Guang-Zhi ^{[1
]}

Kong, Ling-Dong ^{[3
]}

Tan, Ning-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China

[4] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 12期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/np200755t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six novel Ia(3)-type cyclopeptide alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11 beta-HSD1, with IC50 values of 52.0 (human) and 31.2 mu g/mL (mouse).

引用

页码：2571 / 2575

页数：5

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