Galactosylation of human erythropoietin produced by chimeric chickens expressing galactosyltransferase

被引：9

作者：

Kojima, Yusuke ^{[1
]}

Wakita, Jun ^{[1
]}

Inayoshi, Yujin ^{[1
]}

Suzuki, Ryosuke ^{[1
]}

Yamada, Yuki ^{[1
]}

Kaneoka, Hidenori ^{[1
]}

Nishijima, Ken-ichi ^{[1
]}

Iijima, Shinji ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Dept Biotechnol, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2014年 / 117卷 / 06期

关键词：

Transgenic chicken; Erythropoietin; Galactose; Galactosyltransferase; N-Glycan; EGG-WHITE; SUGAR CHAINS; TRANSGENESIS; TRANSPORT; PROTEINS; ANTIBODY; YOLK;

D O I：

10.1016/j.jbiosc.2013.11.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Human erythropoietin produced in the egg white of chimeric chicken contains N-glycan with lower amounts of terminal galactose and sialic acid; therefore, the chicken galactosyltransferase gene was introduced together with the human erythropoietin gene by a retroviral vector. We found that erythropoietin accumulated in the egg white was partially galactosylated. (C) 2013, The Society for Biotechnology, Japan. All rights reserved.

引用

页码：676 / 679

页数：4

共 50 条

[1] Production of human erythropoietin by chimeric chickens
Kodama, Daisuke
Nishimiya, Daisuke
Iwata, Ken-Ichi
Yamaguchi, Kazuhisa
Yoshida, Kazuhiro
Kawabe, Yoshinori
Motono, Makoto
Watanabe, Hiroyuki
Yamashita, Takashi
Nishijima, Ken-ichi
Kamihira, Masamichi
Iijima, Shinji
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 367 (04) : 834 - 839
[2] PRODUCTION OF TRANSGENIC CHICKENS EXPRESSING HUMAN ERYTHROPOIETIN IN A TETRACYCLINE-INDUCIBLE MANNER
Koo, B.
Kwon, M.
Roh, J.
Lee, H.
Kim, N.
Kim, T.
REPRODUCTION FERTILITY AND DEVELOPMENT, 2009, 21 (01) : 249 - 249
[3] In vitro galactosylation of human IgG at 1 kg scale using recombinant galactosyltransferase
Warnock, D
Bai, XM
Autote, K
Gonzales, J
Kinealy, K
Yan, B
Oian, J
Stevenson, T
Zopf, D
Bayer, RJ
BIOTECHNOLOGY AND BIOENGINEERING, 2005, 92 (07) : 831 - 842
[4] GALACTOSYLATION OF NONNATURAL GLYCOSIDES WITH HUMAN BETA-D-GALACTOSYLTRANSFERASE ON A PREPARATIVE SCALE
OHRLEIN, R
ERNST, B
BERGER, EG
CARBOHYDRATE RESEARCH, 1992, 236 : 335 - 338
[5] Transgenic chickens expressing galactosyltransferase produce galactosylated pharmaceutical proteins into egg white
Mizutani, Akifumi
Sasamoto, Takako
Kojima, Yasuhiro
Kojima, Jun
Inayoshi, Yujin
Nishijima, Ken-ichi
Miyake, Katsuhide
Iijima, Shinji
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2009, 108 : S23 - S23
[6] Chimeric plumage coloration produced by ovarian transplantation in chickens
Liu, J.
Robertson, M. C.
Cheng, K. M.
Silversides, F. G.
POULTRY SCIENCE, 2013, 92 (04) : 1073 - 1076
[7] Production of transgenic chickens constitutively expressing human erythropoietin (hEPO): Problems with uncontrollable overexpression of hEPO gene
Bon Chul Koo
Mo Sun Kwon
Dohyang Kim
Sang A. Kim
Nam-Hyung Kim
Teoan Kim
Biotechnology and Bioprocess Engineering, 2017, 22 : 22 - 29
[8] Production of Transgenic Chickens Constitutively Expressing Human Erythropoietin (hEPO): Problems with Uncontrollable Overexpression of hEPO Gene
Koo, Bon Chul
Kwon, Mo Sun
Kim, Dohyang
Kim, Sang A.
Kim, Nam-Hyung
Kim, Teoan
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2017, 22 (01) : 22 - 29
[9] Generation of transgenic chickens producing human erythropoietin
Kim, Teoan
Kwon, Mo
Roh, Ji
Lee, Hyuna
Kim, Naiu-Hyung
Koo, Bon
BIOLOGY OF REPRODUCTION, 2008, : 225 - 225
[10] Generation of transgenic chickens expressing the human erythropoietin (hEPO) gene in an oviduct-specific manner: Production of transgenic chicken eggs containing human erythropoietin in egg whites
Kwon, Mo Sun
Koo, Bon Chul
Kim, Dohyang
Nam, Yu Hwa
Cui, Xiang-Shun
Kim, Nam-Hyung
Kim, Teoan
PLOS ONE, 2018, 13 (05):

← 1 2 3 4 5 →