Recent Advances in Metal-Catalyzed, Electrochemical Coupling Reactions of sp2 Halides/Boronic Acids and sp3 Centers

Traditionally, metal-catalyzed cross-coupling reactions rely on stable but expensive metals, such as palladium. However, the recent development of synthetic organic electrochemistry allows for in situ redox manipulations, expanding the use of cheaper, abundant and sustainable metals, such as nickel and copper as efficient cross-coupling catalysts. This short review covers the recent advances in metal-catalyzed electrochemical coupling reactions, with a focus on reactions of sp(2) electrophiles and nucleophiles with sp(3) coupling partners to form both C-C and C-heteroatom bonds. 1 Introduction 2 Nickel-Catalyzed C-C sp(2)-sp(3) Coupling Reactions 3 Coupling of Aryl Groups with Heteroatomic Nuclei 4 Conclusion