Toxicological mechanisms of Aconitum alkaloids

被引：3
|
作者：
Fu, M.
Wu, M.
Qiao, Y.
Wang, Z. [1 ]
机构：
[1] Tsing Hua Univ, Sch Med, Beijing 100084, Peoples R China
[2] Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
[3] Beijing Univ Chinese Med, Beijing, Peoples R China
来源：
PHARMAZIE | 2006年 / 61卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The toxic effects of Aconitum alkaloids are known to affect mainly the central nervous system, heart and muscle tissues. Their toxicological mechanisms may involve interaction with voltage-dependent Na+ channels, modulation of neurotransmitter release and related receptors, promotion of lipid peroxidation and induction of cell apoptosis in heart, liver or other organs. Of them, the mechanism of interaction with voltage-dependent Na+ channels is quite well known, but the other factors are still unclear, and need to be further studied. This review focuses on the toxicological mechanisms of Aconitum alkaloids.
引用
收藏
页码：735 / 741
页数：7
相关论文
共 50 条
  • [41] Norditerpenoid alkaloids from Aconitum manshuricum
    Ishimi, Katsuhiro
    Makino, Mitsuko
    Asada, Yasuo
    Ichinohe, Yoshiyuki
    Fujimoto, Yasuo
    JOURNAL OF NATURAL MEDICINES, 2006, 60 (03) : 255 - 257
  • [42] Diterpene alkaloids from Aconitum kirinense
    Feng, F
    Liu, JH
    Zhao, SX
    PHYTOCHEMISTRY, 1998, 49 (08) : 2557 - 2559
  • [43] Diterpenoid alkaloids from Aconitum leucostomum
    Yue, JM
    Xu, J
    Zhao, QS
    Sun, HD
    Chen, YZ
    JOURNAL OF NATURAL PRODUCTS, 1996, 59 (03): : 277 - 279
  • [44] A QSAR analysis of toxicity of Aconitum alkaloids
    Bello-Ramírez, AM
    Nava-Ocampo, AA
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2004, 18 (06) : 699 - 704
  • [45] New Alkaloids from Aconitum stapfianum
    Yin T.-P.
    Cai L.
    Li Y.
    Fang Y.-S.
    Peng L.
    Ding Z.-T.
    Natural Products and Bioprospecting, 2015, 5 (6) : 271 - 275
  • [46] ALKALOIDS OF ACONITUM-COLUMBIANUM NUTT
    PELLETIER, SW
    SRIVASTAVA, SK
    JOSHI, BS
    OLSEN, JD
    HETEROCYCLES, 1985, 23 (02) : 331 - 338
  • [47] Diterpenoid alkaloids from aconitum episcopale
    Yang, JH
    Li, ZY
    Li, L
    Wang, YS
    PHYTOCHEMISTRY, 1999, 50 (02) : 345 - 348
  • [48] Diterpenoid alkaloids from Aconitum vilmorinianum
    Yin, Tian-Peng
    Cai, Le
    Fang, Hai-Xian
    Fang, Yun-Shan
    Li, Zhen-Jie
    Ding, Zhong-Tao
    PHYTOCHEMISTRY, 2015, 116 : 314 - 319
  • [49] ALKALOIDS OF ACONITUM KARAKOLICUM - STRUCTURE OF ACETYLNAPELLINE
    SULTANKHODSHAEV, MN
    BESHITAISHVILI, LV
    YUNUSOV, MS
    YUNUSOV, SY
    KHIMIYA PRIRODNYKH SOEDINENII, 1978, (04): : 479 - 482
  • [50] DITERPENOID ALKALOIDS OF ACONITUM-SUNGPANASE
    WANG, R
    CHEN, YZ
    PLANTA MEDICA, 1987, 53 (06) : 544 - 546
12345