Toxicological mechanisms of Aconitum alkaloids

被引：3
|
作者：
Fu, M.
Wu, M.
Qiao, Y.
Wang, Z. [1 ]
机构：
[1] Tsing Hua Univ, Sch Med, Beijing 100084, Peoples R China
[2] Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
[3] Beijing Univ Chinese Med, Beijing, Peoples R China
来源：
PHARMAZIE | 2006年 / 61卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The toxic effects of Aconitum alkaloids are known to affect mainly the central nervous system, heart and muscle tissues. Their toxicological mechanisms may involve interaction with voltage-dependent Na+ channels, modulation of neurotransmitter release and related receptors, promotion of lipid peroxidation and induction of cell apoptosis in heart, liver or other organs. Of them, the mechanism of interaction with voltage-dependent Na+ channels is quite well known, but the other factors are still unclear, and need to be further studied. This review focuses on the toxicological mechanisms of Aconitum alkaloids.
引用
收藏
页码：735 / 741
页数：7
相关论文
共 50 条
  • [31] ALKALOIDS ACONITUM-ZERAVSCHANICUM
    VAISOV, ZM
    SALIMOV, BT
    TASHKHODZHAEV, B
    YUNUSOV, MS
    KHIMIYA PRIRODNYKH SOEDINENII, 1986, (05): : 658 - 659
  • [32] ALKALOIDS OF ACONITUM-VIOLACEUM
    MIANA, GA
    IKRAM, M
    KHAN, MI
    SULTANA, F
    PHYTOCHEMISTRY, 1971, 10 (12) : 3320 - &
  • [33] ALKALOIDS OF ACONITUM-KARAKOLICUM
    SULTANKHODZHAEV, MN
    YUNUSOV, MS
    YUNUSOV, SY
    KHIMIYA PRIRODNYKH SOEDINENII, 1973, (01): : 127 - 128
  • [34] Diterpene Alkaloids from Aconitum anthora and Assessment of the hERG-Inhibiting Ability of Aconitum Alkaloids
    Forgo, Peter
    Borcsa, Botond
    Csupor, Dezso
    Fodor, Laszlo
    Robert Berkecz
    Molnar, Attila, V
    Hohmann, Judit
    PLANTA MEDICA, 2011, 77 (04) : 368 - 373
  • [35] Norditerpenoid alkaloids from Aconitum transsectum
    Zheng, SZ
    Gao, LM
    Hao, XJ
    Wang, XX
    Shen, XW
    PHYTOCHEMISTRY, 1997, 46 (05) : 951 - 954
  • [36] Norditerpenoid alkaloids from Aconitum manshuricum
    Katsuhiro Ishimi
    Mitsuko Makino
    Yasuo Asada
    Yoshiyuki Ichinohe
    Yasuo Fujimoto
    Journal of Natural Medicines, 2006, 60 : 255 - 257
  • [37] Alkaloids from roots of Aconitum monticola
    E. V. Burdel’naya
    M. A. Zhunusova
    A. Zh. Turmukhambetov
    R. B. Seidakhmetova
    E. E. Shul’ts
    Yu. V. Gatilov
    S. M. Adekenov
    Chemistry of Natural Compounds, 2012, 47 : 1032 - 1034
  • [38] Diterpenoid alkaloids from Aconitum tanguticum
    Qu, Shi-Jin
    Tan, Chang-Heng
    Liu, Zu-Long
    Jiang, Shan-Hao
    Yu, Long
    Zhu, Da-Yuan
    PHYTOCHEMISTRY LETTERS, 2011, 4 (02) : 144 - 146
  • [39] ACCUMULATION DYNAMICS OF ALKALOIDS IN Aconitum talassicum
    Eshmatov, Zh M.
    Sultankhodzhaev, M. N.
    Nigmatullaev, A. M.
    CHEMISTRY OF NATURAL COMPOUNDS, 2011, 47 (01) : 149 - 150
  • [40] ALKALOIDS FROM ROOTS OF Aconitum monticola
    Burdel'naya, E. V.
    Zhunusova, M. A.
    Turmukhambetov, A. Zh.
    Seidakhmetova, R. B.
    Shul'ts, E. E.
    Gatilov, Yu. V.
    Adekenov, S. M.
    CHEMISTRY OF NATURAL COMPOUNDS, 2012, 47 (06) : 1032 - 1034
12345