Toxicological mechanisms of Aconitum alkaloids

被引：3
|
作者：
Fu, M.
Wu, M.
Qiao, Y.
Wang, Z. [1 ]
机构：
[1] Tsing Hua Univ, Sch Med, Beijing 100084, Peoples R China
[2] Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
[3] Beijing Univ Chinese Med, Beijing, Peoples R China
来源：
PHARMAZIE | 2006年 / 61卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The toxic effects of Aconitum alkaloids are known to affect mainly the central nervous system, heart and muscle tissues. Their toxicological mechanisms may involve interaction with voltage-dependent Na+ channels, modulation of neurotransmitter release and related receptors, promotion of lipid peroxidation and induction of cell apoptosis in heart, liver or other organs. Of them, the mechanism of interaction with voltage-dependent Na+ channels is quite well known, but the other factors are still unclear, and need to be further studied. This review focuses on the toxicological mechanisms of Aconitum alkaloids.
引用
收藏
页码：735 / 741
页数：7
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