DABSO-Based, Three-Component, One-Pot Sulfone Synthesis

被引：187
|
作者：
Deeming, Alex S. [1 ]
Russell, Claire J. [2 ]
Hennessy, Alan J. [2 ]
Willis, Michael C. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
[2] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 01期
基金：
英国工程与自然科学研究理事会;
关键词：
PALLADIUM-CATALYZED AMINOSULFONYLATION; ARYL SULFONES; BIOLOGICAL-ACTIVITY; INHIBITORS; EFFICIENT; ALKYLATION; ARYLATION; OXIDATION; ALDEHYDES; HALIDES;
D O I：
10.1021/ol403122a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The addition of Grignard reagents or organolithium reagents to the SO2-surrogate DABSO generates a diverse set of metal sulfinates, suitable for direct conversion to sulfone products. The metal sulfinates can be trapped in situ with a wide range of C-electrophiles, including alkyl, allyl, and benzyl halides, epoxides, and (hetero)aryliodoniums.
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页码：150 / 153
页数：4
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