METAL-FREE, ONE-POT OXIDATIVE CONVERSION OF ALDEHYDES TO PRIMARY THIOAMIDES IN AQUEOUS MEDIA

被引：12

作者：

Yadav, Arvind K. ^{[1
]}

Srivastava, Vishnu P. ^{[1
]}

Yadav, Lal Dhar S. ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Green Synth Lab, Allahabad 211002, Uttar Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2014年 / 44卷 / 03期

关键词：

Aldehydes; deoxygenation; green chemistry; nitriles; O; O-diethyl dithiophosphopric acid; thioamides; SOLVENT-FREE SYNTHESIS; DIPHENYLPHOSPHINODITHIOIC ACID; EFFICIENT; REAGENT; CYCLIZATION; THIONATION; NITRILES; AMIDE; STEREOCHEMISTRY; COMBINATION;

D O I：

10.1080/00397911.2013.808350

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

引用

页码：408 / 416

页数：9

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