Severe Pancytopenia Induced by Valproic Acid

被引：4
|
作者：
Wahba, Andrew [1 ]
Bergez, Emmalee [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, Pediat, McGovern Med Sch, Houston, TX 77030 USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2020年 / 12卷 / 10期
关键词：
bone marrow suppression; pancytopenia; valproic acid; PHARMACOKINETICS; THROMBOCYTOPENIA; TOXICITY; THERAPY; SCN1A;
D O I：
10.7759/cureus.11252
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mcg/mL. Reported cases indicate an increased incidence of hematologic toxicity; however, evidence for management is limited. We report a case of bone marrow suppression induced by a high dose of valproic acid in a 10-year-old male.
引用
收藏
页数：4
相关论文
共 50 条
  • [41] Effect of a Declined Plasma Concentration of Valproic Acid Induced by Meropenem on the Antiepileptic Efficacy of Valproic Acid
    Gu, Chunping
    Zhang, Yongfang
    Yuan, Fumiao
    Huang, Kaibin
    Lin, Zhenzhou
    Chen, Qiong
    Chen, Yan
    Wu, Yongming
    Wang, Dongmei
    Wang, Shengnan
    JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2024, 38 (08)
  • [42] Carnitine for valproic acid-induced hyperammonemia
    Raby, WN
    AMERICAN JOURNAL OF PSYCHIATRY, 1997, 154 (08): : 1168 - 1169
  • [43] Hypothermia and thermoregulatory derangements induced by valproic acid
    Zachariah, SB
    Zachariah, A
    Ananda, R
    Stewart, JT
    NEUROLOGY, 2000, 55 (01) : 150 - 151
  • [44] Valproic acid-induced acute pancreatitis
    Jain, Ayush
    Haque, Ijasul
    Tayal, Vandana
    Roy, Vandana
    INDIAN JOURNAL OF PSYCHIATRY, 2019, 61 (04) : 421 - 422
  • [45] ACUTE-PANCREATITIS INDUCED BY VALPROIC ACID
    CROIZET, O
    LOUVEL, D
    TEULIERE, JP
    BUSCAIL, L
    ESCOURROU, J
    FREXINOS, J
    GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 1994, 18 (10): : 910 - 911
  • [46] CHANGE IN HAIR COLOR INDUCED BY VALPROIC ACID
    HERRANZ, JL
    ARTEAGA, R
    ARMIJO, JA
    DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 1981, 23 (03): : 386 - 387
  • [47] Valproic acid and zonisamide induced hyperammonemic encephalopathy
    Ilieva, Hristelina S.
    Newman, Joseph W.
    Fields, Ronald K.
    Croom, John E.
    CLINICAL NEUROLOGY AND NEUROSURGERY, 2020, 196
  • [48] Valproic acid induced pancreatitis revisited.
    Buckley, DJ
    Prasad, AN
    Penney, S
    EPILEPSIA, 1999, 40 : 181 - 181
  • [49] Hyperammonemia and valproic acid-induced encephalopathy
    Modjtahedi, Bobeck
    Xiong, Glen L.
    AMERICAN JOURNAL OF PSYCHIATRY, 2007, 164 (12): : 1912 - 1913
  • [50] Neutropenia induced by Valproic Acid: A case report
    Baldaqui, N.
    Anmella, G.
    Madero, S.
    Gutierrez, F.
    Pujal, E.
    Colomer, L.
    Gimenez-Palomo, A.
    EUROPEAN PSYCHIATRY, 2022, 65 : S731 - S732
12345