Severe Pancytopenia Induced by Valproic Acid

被引：4
|
作者：
Wahba, Andrew [1 ]
Bergez, Emmalee [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, Pediat, McGovern Med Sch, Houston, TX 77030 USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2020年 / 12卷 / 10期
关键词：
bone marrow suppression; pancytopenia; valproic acid; PHARMACOKINETICS; THROMBOCYTOPENIA; TOXICITY; THERAPY; SCN1A;
D O I：
10.7759/cureus.11252
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mcg/mL. Reported cases indicate an increased incidence of hematologic toxicity; however, evidence for management is limited. We report a case of bone marrow suppression induced by a high dose of valproic acid in a 10-year-old male.
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页数：4
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