Severe Pancytopenia Induced by Valproic Acid

被引：4

作者：

Wahba, Andrew ^{[1
]}

Bergez, Emmalee ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Pediat, McGovern Med Sch, Houston, TX 77030 USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2020年 / 12卷 / 10期

关键词：

bone marrow suppression; pancytopenia; valproic acid; PHARMACOKINETICS; THROMBOCYTOPENIA; TOXICITY; THERAPY; SCN1A;

D O I：

10.7759/cureus.11252

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Valproic acid is commonly used to treat pediatric epilepsy. This drug is usually well-tolerated; its side effects are typically mild, with hepatotoxicity being the most widely recognized one. Bone marrow suppression is a rarely seen complication in patients with valproic acid levels more than 125 mcg/mL. Reported cases indicate an increased incidence of hematologic toxicity; however, evidence for management is limited. We report a case of bone marrow suppression induced by a high dose of valproic acid in a 10-year-old male.

引用

页数：4

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