Phosphorylation of Helicobacter pylori CagA in patients with gastric ulcer and gastritis

被引：2

作者：

Cheng, KS ^{[1
]}

Lu, MC ^{[1
]}

Tang, HL ^{[1
]}

Chou, FT ^{[1
]}

机构：

[1] China Med Coll Hosp, Dept Internal Med, Div Gastroenterol, Taichung 40421, Taiwan

来源：

ADVANCES IN THERAPY | 2002年 / 19卷 / 02期

关键词：

type IV phosphorylation; pathogenicity island; gastritis; gastric ulcer;

D O I：

10.1007/BF02850057

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of Helicobacter pylori infection are strongly associated with chronic gastritis, gastric and duodenal ulcer, gastric cancer, and MALT lymphoma. The microorganism has been classified as a type I carcinogen by the World Health Organization. Varying clinical results from H. pylori infection are believed due, in part, to differences in virulence among species. The cag pathogenicity island is a complex of virulent genes and a coding region for the type IV phosphorylated secretion system. Through this system, many virulent gene products or proteins are phosphorylated into the host cells. This study demonstrated the positive CagA-phosphorylation effect of H. pylori in patients with chronic gastritis and benign gastric ulcer and revealed significantly different rates of CagA phosphorylation between these two diseases (P<.05).

引用

页码：85 / 90

页数：6

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