Phosphorylation of Helicobacter pylori CagA in patients with gastric ulcer and gastritis

被引：2
|
作者：
Cheng, KS [1 ]
Lu, MC [1 ]
Tang, HL [1 ]
Chou, FT [1 ]
机构：
[1] China Med Coll Hosp, Dept Internal Med, Div Gastroenterol, Taichung 40421, Taiwan
来源：
ADVANCES IN THERAPY | 2002年 / 19卷 / 02期
关键词：
type IV phosphorylation; pathogenicity island; gastritis; gastric ulcer;
D O I：
10.1007/BF02850057
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of Helicobacter pylori infection are strongly associated with chronic gastritis, gastric and duodenal ulcer, gastric cancer, and MALT lymphoma. The microorganism has been classified as a type I carcinogen by the World Health Organization. Varying clinical results from H. pylori infection are believed due, in part, to differences in virulence among species. The cag pathogenicity island is a complex of virulent genes and a coding region for the type IV phosphorylated secretion system. Through this system, many virulent gene products or proteins are phosphorylated into the host cells. This study demonstrated the positive CagA-phosphorylation effect of H. pylori in patients with chronic gastritis and benign gastric ulcer and revealed significantly different rates of CagA phosphorylation between these two diseases (P<.05).
引用
收藏
页码：85 / 90
页数：6
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