Inhibitors of bacterial signal peptidase: A series of 6-(substituted oxyethyl)penems

被引：36

作者：

Allsop, A ^{[1
]}

Brooks, G ^{[1
]}

Edwards, PD ^{[1
]}

Kaura, AC ^{[1
]}

Southgate, R ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 09期

关键词：

D O I：

10.7164/antibiotics.49.921

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.

引用

页码：921 / 928

页数：8

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