Inhibitors of bacterial signal peptidase: A series of 6-(substituted oxyethyl)penems

被引：36
|
作者：
Allsop, A [1 ]
Brooks, G [1 ]
Edwards, PD [1 ]
Kaura, AC [1 ]
Southgate, R [1 ]
机构：
[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND
来源：
JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 09期
关键词：
D O I：
10.7164/antibiotics.49.921
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.
引用
收藏
页码：921 / 928
页数：8
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