The burden of the HIV viral load and of cell-to-cell spread in HIV/HCV coinfection

被引：4
|
作者：
Carvalho, Ana R. M. [1 ]
Pinto, Carla M. A. [2 ]
机构：
[1] Univ Porto, Fac Sci, Rua Campo Alegre S-N, P-4440452 Porto, Portugal
[2] Polytech Porto, Sch Engn, Rua Dr Antonio Bernardino de Almeida 431, P-4200072 Porto, Portugal
来源：
IFAC PAPERSONLINE | 2018年 / 51卷 / 02期
关键词：
HIV; HCV; coinfection; cell-to-cell transmission; fractional order model; FRACTIONAL-ORDER MODEL; DRUG-RESISTANCE; DYNAMICS; HCV; TRANSMISSION;
D O I：
10.1016/j.ifacol.2018.03.063
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
We study the burden of the HIV viral load and of the cell-to-cell transmission on the dynamics of a fractional model for HIV/HCV coinfection. The model includes treatment for HCV. We calculate the reproduction number of the model and the local stability of the disease free equilibrium. Simulations of the model reveal the effect of the HIV viral load, of cell-to-cell transmission, and of the order of the fractional derivative on the dynamics of the coinfection. The results are explained using an epidemiological approach. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.
引用
收藏
页码：367 / 372
页数：6
相关论文
共 50 条
  • [41] The Burgeoning HIV/HCV Syndemic in the Urban Northeast: HCV, HIV, and HIV/HCV Coinfection in an Urban Setting
    Morano, Jamie P.
    Gibson, Britton A.
    Altice, Frederick L.
    PLOS ONE, 2013, 8 (05):
  • [42] Stability of a general adaptive immunity HIV infection model with silent infected cell-to-cell spread
    AlShamrani, N. H.
    CHAOS SOLITONS & FRACTALS, 2021, 150
  • [43] Viral hepatitis and HIV coinfection
    Bourliere, M.
    Fontaine, H.
    Yazdanpanah, Y.
    Piroth, L.
    Benhamou, Y.
    JOURNAL AFRICAIN D HEPATO-GASTROENTEROLOGIE, 2007, 1 (01): : 38 - 50
  • [44] Viral hepatitis and HIV coinfection
    Sulkowski, Mark S.
    JOURNAL OF HEPATOLOGY, 2008, 48 (02) : 353 - 367
  • [45] ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation
    Sol-Foulon, Nathalie
    Sourisseau, Marion
    Porrot, Francoise
    Thoulouze, Maria-Isabel
    Trouillet, Celine
    Nobile, Cinzia
    Blanchet, Fabien
    di Bartolo, Vincenzo
    Noraz, Nelly
    Taylor, Naomi
    Alcover, Andres
    Hivroz, Claire
    Schwartz, Olivier
    EMBO JOURNAL, 2007, 26 (02): : 516 - 526
  • [46] Stability of an adaptive immunity delayed HIV infection model with active and silent cell-to-cell spread
    Elaiw, A. M.
    AlShamrani, N. H.
    Hobiny, A. D.
    MATHEMATICAL BIOSCIENCES AND ENGINEERING, 2020, 17 (06) : 6401 - 6458
  • [47] HIV and Viral Hepatitis Coinfection
    Varnholt, Heike
    Dezube, Bruce J.
    Pantanowitz, Liron
    AIDS READER, 2008, 18 (12): : 613 - 614
  • [48] Optimizing treatment in HIV/HCV coinfection
    Puoti, Massimo
    Rossotti, Roberto
    Travi, Giovanna
    Panzeri, Claudia
    Morreale, Marco
    Chiari, Erika
    Cocca, Giorgia
    Orso, Maurizio
    Moioli, Maria Cristina
    DIGESTIVE AND LIVER DISEASE, 2013, 45 : S355 - S362
  • [49] IMMUNOLOGICAL ASPECTS OF HCV/HIV COINFECTION
    Yuschuk, N. D.
    Shestakova, I. V.
    Balmasova, I. P.
    Vysheslavtseva, M. V.
    Shmeleva, E. V.
    TERAPEVTICHESKII ARKHIV, 2011, 83 (11) : 9 - 14
  • [50] Advances in the management of HIV/HCV coinfection
    Mattias Mandorfer
    Philipp Schwabl
    Sebastian Steiner
    Thomas Reiberger
    Markus Peck-Radosavljevic
    Hepatology International, 2016, 10 : 424 - 435
12345