Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax)

被引：1

作者：

Svishcheva, M., V ^{[1
]}

Mishina, Ye S. ^{[1
]}

Medvedeva, O. A. ^{[1
]}

Bobyntsev, I. I. ^{[1
]}

Mukhina, A. Y. ^{[1
]}

Kalutskii, P., V ^{[1
]}

Andreeva, L. A. ^{[2
]}

Myasoedov, N. F. ^{[2
]}

机构：

[1] Kursk State Med Univ, Minist Hlth Russian Federat, Kursk, Russia

[2] Russian Acad Sci, Inst Mol Genet, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 170卷 / 03期

关键词：

Semax; restraint stress; colon; corticosterone;

D O I：

10.1007/s10517-021-05072-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of intraperitoneal administration ACTH((4-7))-PGP in doses of 5, 50, 150, and 450 mu g/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon. In rats exposed to restraint stress, signs of atrophy and inflammatory reaction in the colon wall, changes in functional activity and number of mast cells, and increased serum level of corticosterone were observed. Administration of the peptide led to a decrease in corticosterone concentration, alleviated stress-induced pathomorphological changes, and promoted adaptation of the intestinal wall to stress. The positive effects of ACTH((4-7))-PGP can be determined by multifunctional nature of the physiological and pharmacological effects of the neuropeptide.

引用

页码：384 / 388

页数：5

共 23 条

[1] Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax)
M. V. Svishcheva
Ye. S. Mishina
O. A. Medvedeva
I. I. Bobyntsev
A. Y. Mukhina
P. V. Kalutskii
L. A. Andreeva
N. F. Myasoedov
Bulletin of Experimental Biology and Medicine, 2021, 170 : 384 - 388
[2] Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress
Svishcheva, M. V.
Mukhina, A. Yu.
Medvedeva, O. A.
Shevchenko, A. V.
Bobyntsev, I. I.
Kalutskii, P. V.
Andreeva, L. A.
Myasoedov, N. F.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2020, 169 (03) : 357 - 360
[3] Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress
M. V. Svishcheva
A. Yu. Mukhina
O. A. Medvedeva
A. V. Shevchenko
I. I. Bobyntsev
P. V. Kalutskii
L. A. Andreeva
N. F. Myasoedov
Bulletin of Experimental Biology and Medicine, 2020, 169 : 357 - 360
[4] Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats
Filippenkov, Ivan B.
Stavchansky, Vasily V.
Denisova, Alina E.
Yuzhakov, Vadim V.
Sevan'kaeva, Larisa E.
Sudarkina, Olga Y.
Dmitrieva, Veronika G.
Gubsky, Leonid, V
Myasoedov, Nikolai F.
Limborska, Svetlana A.
Dergunova, Lyudmila, V
GENES, 2020, 11 (06) : 1 - 16
[5] Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress
A. V. Ivanov
I. I. Bobyntsev
O. M. Shepeleva
A. A. Kryukov
L. A. Andreeva
N. F. Myasoedov
Bulletin of Experimental Biology and Medicine, 2017, 163 : 105 - 108
[6] Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress
Ivanov, A. V.
Bobyntsev, I. I.
Shepeleva, O. M.
Kryukov, A. A.
Andreeva, L. A.
Myasoedov, N. F.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2017, 163 (01) : 105 - 108
[7] The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain
Dergunova, L., V
Dmitrieva, V. G.
Filippenkov, I. B.
Stavchansky, V. V.
Denisova, A. E.
Yuzhakov, V. V.
Sevan'kaeva, L. E.
Valieva, L. V.
Sudarkina, O. Y.
Gubsky, L., V
Myasoedov, N. F.
Limborska, S. A.
MOLECULAR BIOLOGY, 2021, 55 (03) : 346 - 353
[8] Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion
Sudarkina, Olga Yu
Filippenkov, Ivan B.
Stavchansky, Vasily V.
Denisova, Alina E.
Yuzhakov, Vadim V.
Sevan'Kaeva, Larisa E.
Valieva, Liya V.
Remizova, Julia A.
Dmitrieva, Veronika G.
Gubsky, Leonid, V
Myasoedov, Nikolai F.
Limborska, Svetlana A.
Dergunova, Lyudmila, V
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (12)
[9] Effects of the ACTH6-9-Pro-Gly-Pro peptide on the morphofunctional state of rat colon under conditions of chronic restraint stress
Vorvul, A. O.
Bobyntsev, I. I.
Mishina, E. S.
Medvedeva, O. A.
Andreeva, L. A.
Myasoedov, N. F.
BYULLETEN SIBIRSKOY MEDITSINY, 2023, 22 (02): : 14 - 20
[10] The Peptide ACTH4–7-PGP Corrects Behavior and Corticosterone Levels in Rats in Chronic Stress
Vorvul A.O.
Bobyntsev I.I.
Svishcheva M.V.
Medvedeva O.A.
Mukhina A.Y.
Andreeva L.A.
Neuroscience and Behavioral Physiology, 2022, 52 (4) : 574 - 581

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