Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax)

被引：1

作者：

Svishcheva, M., V ^{[1
]}

Mishina, Ye S. ^{[1
]}

Medvedeva, O. A. ^{[1
]}

Bobyntsev, I. I. ^{[1
]}

Mukhina, A. Y. ^{[1
]}

Kalutskii, P., V ^{[1
]}

Andreeva, L. A. ^{[2
]}

Myasoedov, N. F. ^{[2
]}

机构：

[1] Kursk State Med Univ, Minist Hlth Russian Federat, Kursk, Russia

[2] Russian Acad Sci, Inst Mol Genet, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 170卷 / 03期

关键词：

Semax; restraint stress; colon; corticosterone;

D O I：

10.1007/s10517-021-05072-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of intraperitoneal administration ACTH((4-7))-PGP in doses of 5, 50, 150, and 450 mu g/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon. In rats exposed to restraint stress, signs of atrophy and inflammatory reaction in the colon wall, changes in functional activity and number of mast cells, and increased serum level of corticosterone were observed. Administration of the peptide led to a decrease in corticosterone concentration, alleviated stress-induced pathomorphological changes, and promoted adaptation of the intestinal wall to stress. The positive effects of ACTH((4-7))-PGP can be determined by multifunctional nature of the physiological and pharmacological effects of the neuropeptide.

引用

页码：384 / 388

页数：5

共 23 条

[21] Morphofunctional State of the Adrenal Glands in Albino Rats under Conditions of Toxic Stress Caused by Cadmium Salt in Winter and Summer Periods
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[22] ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress
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Bobyntsev, Igor I.
Medvedeva, Olga A.
Mukhina, Alexandra Y.
V. Svishcheva, Maria
Azarova, Iuliia E.
Andreeva, Lyudmila A.
Myasoedov, Nikolay F.
NEUROPEPTIDES, 2022, 93
[23] HIPPOCAMPAL THETA-2 ACTIVITY (4-7 HZ) DURING DIFFERENT PHASES OF CHRONIC INESCAPABLE STRESS IN RATS AS A POSSIBLE MEASURE FOR CHANGES IN THE FUNCTIONAL-STATE OF THE BASAL FOREBRAIN CHOLINERGIC SYSTEM (BFCS)
NIKOLOV, ND
MASLAROV, DB
TOTEV, AN
HARLEVA, SA
DOKLADI NA BOLGARSKATA AKADEMIYA NA NAUKITE, 1992, 45 (04): : 105 - 107

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