Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress

被引：4
|
作者：
Svishcheva, M. V. [1 ]
Mukhina, A. Yu. [1 ]
Medvedeva, O. A. [1 ]
Shevchenko, A. V. [1 ]
Bobyntsev, I. I. [1 ]
Kalutskii, P. V. [1 ]
Andreeva, L. A. [2 ]
Myasoedov, N. F. [2 ]
机构：
[1] Kursk State Med Univ, Minist Hlth Russian Federat, Kursk, Russia
[2] Russian Acad Sci, Inst Mol Genet, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 169卷 / 03期
关键词：
microbiota; dysbiosis; Semax; restraint stress; colon; BEHAVIOR;
D O I：
10.1007/s10517-020-04886-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of Semax on the state of intestinal microbiota in rats subjected to restraint stress. Semax was injected to Wistar male rats intraperitoneally in doses of 5, 50, 150, 450 mu g/kg 12-15 min before modelling chronic restraint stress. It was found that stress exposure reduced the number of obligate bacteria in the colon microbiota, but increased the content of opportunistic microorganisms. Semax in doses of 50 and 150 mu g/kg prevented the stress-induced changes in the composition of colon microbiota. The observed effects of Semax might be mediated by the central neurotropic effects as well as by binding to peripheral melanocortin receptors of the intestine.
引用
收藏
页码：357 / 360
页数：4
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