Analytical HPLC Method for Dorzolamide and Timolol Assay in Ophthalmic Solution: Development, Validation and Application for Drug Product Analysis

被引：0

作者：

Alvarez, Maria P. ^{[1
]}

Genoud, Maria A. ^{[1
]}

Saint Martin, Eduardo E. ^{[1
]}

Gomez, Matias ^{[1
]}

Spinetto, Marta ^{[1
]}

机构：

[1] Adm Nacl Med Alimentos & Tecnol Med ANMAT, Inst Nacl Med, Av Caseros 2161, Buenos Aires, DF, Argentina

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 04期

关键词：

dorzolamide; ophthalmic solution; timolol; validation;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This work describes the development and validation of an analytical HPLC method for dorzolamide hydrochloride and timolol maleate in ophthalmic solution. The aim of this research was to achieve a simple, linear, accurate, precise and robust method to be applied in the drug product analysis. At the end of work, the United Stated Pharmacopoeia already had its own encoded method, however, ours shows to be simpler than that, having the operational advantage of analyzing both active ingredients in the same chromatographic system.

引用

页码：658 / 664

页数：7

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