Contributions of a finite element model for the geometric optimization of an implantable bioartificial pancreas

被引：12

作者：

Dulong, JL ^{[1
]}

Legallais, C ^{[1
]}

机构：

[1] Univ Technol Compiegne, Lab Biomec & Genie Biomed, CNRS, UMR 6600,Dept Biol Engn, F-60205 Compiegne, France

来源：

ARTIFICIAL ORGANS | 2002年 / 26卷 / 07期

关键词：

bioartificial pancreas; finite element method; hollow fiber; islet density; oxygen mass transfer;

D O I：

10.1046/j.1525-1594.2002.07080.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The extravascular implantation of islets of Langerhans immunoprotected within a permselective membrane is a promising method to treat diabetes mellitus. However, oxygen limitation due to purely diffusive solute transport was considered to provoke tissue necrosis and graft failure. We built a solute transport model based on a finite element method aiming at optimizing the hollow fiber geometry. With a low islet density, the influence of oxygen axial flux inside the fiber was underlined and a characteristic length for oxygen supply was introduced. This study allowed the conclusion that islet density must be adapted to the fiber diameter chosen for implantation.

引用

页码：583 / 589

页数：7

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