Reduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine

被引：18

作者：

Odabasi, Z. ^{[1
]}

Karaalp, A. ^{[1
]}

Cermik, H. ^{[2
]}

Mohr, J. ^{[3
]}

Tigen, E. T. ^{[1
]}

Koc, M. ^{[1
]}

Korten, V. ^{[1
]}

机构：

[1] Marmara Univ, Sch Med, Istanbul, Turkey

[2] Etimesgut Mil Hosp, Ankara, Turkey

[3] Univ Texas Houston, Sch Med, Houston, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 07期

关键词：

LIPID FORMULATIONS; NEPHROTOXICITY; DEOXYCHOLATE; TOXICITY; NEPHROPATHY; PREVENTION; 5-PERCENT; TOLERANCE; EMULSION; DEXTROSE;

D O I：

10.1128/AAC.00001-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).

引用

页码：3100 / 3102

页数：3

共 50 条

[31] DMPS and N-acetylcysteine induced renal toxicity in mice exposed to mercury
Ricardo Brandão
Francielli W. Santos
Gilson Zeni
João B. T. Rocha
Cristina W. Nogueira
Biometals, 2006, 19
[32] Risk factors for amphotericin B-induced nephrotoxicity
Luber, AD
Maa, L
Lam, M
Guglielmo, BJ
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 43 (02) : 267 - 271
[33] The effect of amiloride on amphotericin B-induced hypokalaemia
Bearden, DT
Muncey, LA
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 (01) : 109 - 111
[34] AMPHOTERICIN B-INDUCED ABNORMALITIES IN HUMAN PLATELETS
PASTAKIA, KB
TERLE, DA
BROWNSON, NE
POINDEXTER, BJ
BLOOD, 1993, 82 (10) : A162 - A162
[35] MODULATION BY LIPOPROTEINS OF AMPHOTERICIN B-INDUCED IMMUNOSTIMULATION
LITTLE, JR
SHORE, V
CELLULAR IMMUNOLOGY, 1985, 93 (01) : 212 - 221
[36] Amphotericin B-induced hypothermia not proven - Reply
Guglielmo, BJ
Luber, AD
Jacobs, RA
CLINICAL INFECTIOUS DISEASES, 1997, 25 (03) : 757 - 757
[37] PREVENTION OF AMPHOTERICIN B-INDUCED NEPHROTOXICITY WITH MANNITOL
DUNSWORTH, TS
MAURO, LS
DRUG INTELLIGENCE & CLINICAL PHARMACY, 1988, 22 (04): : 327 - 328
[38] ERYTHROPOIETIN CONCENTRATION IN AMPHOTERICIN B-INDUCED ANEMIA
MACGREGOR, RR
BENNETT, JE
ERSLEV, AJ
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 14 (02) : 270 - 273
[39] Role of cytoskeleton in amphotericin B-induced necrosis
Miyake, Masao
Hazama, Akihiro
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010, 60 : S110 - S110
[40] Mechanisms and management of amphotericin B-induced nephrotoxicity
Miano-Manson, TM
CANCER PRACTICE, 1997, 5 (03) : 176 - 181

← 1 2 3 4 5 →