Reduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine

被引：18
|
作者：
Odabasi, Z. [1 ]
Karaalp, A. [1 ]
Cermik, H. [2 ]
Mohr, J. [3 ]
Tigen, E. T. [1 ]
Koc, M. [1 ]
Korten, V. [1 ]
机构：
[1] Marmara Univ, Sch Med, Istanbul, Turkey
[2] Etimesgut Mil Hosp, Ankara, Turkey
[3] Univ Texas Houston, Sch Med, Houston, TX USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 07期
关键词：
LIPID FORMULATIONS; NEPHROTOXICITY; DEOXYCHOLATE; TOXICITY; NEPHROPATHY; PREVENTION; 5-PERCENT; TOLERANCE; EMULSION; DEXTROSE;
D O I：
10.1128/AAC.00001-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).
引用
收藏
页码：3100 / 3102
页数：3
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