Reduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine

被引：18

作者：

Odabasi, Z. ^{[1
]}

Karaalp, A. ^{[1
]}

Cermik, H. ^{[2
]}

Mohr, J. ^{[3
]}

Tigen, E. T. ^{[1
]}

Koc, M. ^{[1
]}

Korten, V. ^{[1
]}

机构：

[1] Marmara Univ, Sch Med, Istanbul, Turkey

[2] Etimesgut Mil Hosp, Ankara, Turkey

[3] Univ Texas Houston, Sch Med, Houston, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 07期

关键词：

LIPID FORMULATIONS; NEPHROTOXICITY; DEOXYCHOLATE; TOXICITY; NEPHROPATHY; PREVENTION; 5-PERCENT; TOLERANCE; EMULSION; DEXTROSE;

D O I：

10.1128/AAC.00001-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).

引用

页码：3100 / 3102

页数：3

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