Metal complexes of Taxol precursor - 1. Synthesis, characterization and antitumor activity of the copper complex of 10-deacetylbaccatin thiosemicarbazone

被引：32
|
作者：
Murugkar, A
Padhye, S [1 ]
Guha-Roy, S
Wagh, U
机构：
[1] Univ Pune, Dept Chem, Pune 411007, Maharashtra, India
[2] Natl Ctr Cell Sci, Pune 411007, Maharashtra, India
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 1999年 / 2卷 / 11期
关键词：
10-DAB; Taxol; copper complexes; thiosemicarbazone;
D O I：
10.1016/S1387-7003(99)00152-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Incorporation of the thiosemicarbazone pharmacophore in the otherwise inactive baccatin nucleus, viz. 10-deacetylbaccatin (10-DAB), on complexation with copper renders a highly antiproliferative compound Cu-DABTSC. When tested on a human breast cancer cell line, MCF-7, it was observed that 10-DAB treated cells were growth arrested but viable whereas Cu-DABTSC was lethal to cells at comparative doses. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
下载
收藏
页码：545 / 548
页数：4
相关论文
共 50 条
  • [31] Binuclear copper(II) complexes 1: Synthesis, characterization and evaluation of a new complex in phosphatase-like activity
    Schicke, Olivier
    Faure, Bruno
    Giorgi, Michel
    Simaan, A. Jalila
    Reglier, Marius
    INORGANICA CHIMICA ACTA, 2012, 391 : 189 - 194
  • [32] A NEW CLASS OF METAL CYANO-COMPLEXES .1. PREPARATION AND NATURE OF COPPER COMPLEX
    TOBIA, SK
    ELSHAHAT, MF
    JOURNAL OF THE CHEMICAL SOCIETY A -INORGANIC PHYSICAL THEORETICAL, 1968, (10): : 2444 - &
  • [33] SYNTHESIS AND CHARACTERIZATION OF BRIDGED BIMETALLIC COMPLEXES .1. COPPER(II) COMPLEXES WITH CONJUGATED DIIMINE LIGANDS
    WANG, WJ
    HO, CT
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1985, 32 (04) : 431 - 438
  • [34] Bioactive Thiosemicarbazone Coordination Metal Complexes: Synthesis, Characterization, Theoretical analysis, Biological Activity, Molecular Docking and ADME analysis
    Jain, Pallavi
    Vishvakarma, Vijay K. K.
    Singh, Prashant
    Yadav, Sandeep
    Kumar, Rajesh
    Chandra, Sulekh
    Kumar, Dinesh
    Misra, Namita
    CHEMISTRY & BIODIVERSITY, 2023, 20 (08)
  • [35] Synthesis, Characterization and Antimicrobial Activity of N-(N,N-Diethylaminobenzyl)thiosemicarbazone and Its Transition Metal Complexes
    Kasim, A. N. Mohamed
    Srinivasan, R.
    ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (04) : 2589 - 2592
  • [36] Synthesis, characterization, antimicrobial activity and molecular docking study of transition metal complexes based on azo coumarin and thiosemicarbazone derivative
    Borhade, Shobha S.
    Tryambake, Pravin T.
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2024, 21 (03) : 719 - 730
  • [37] Synthesis, characterization, antimicrobial activity and molecular docking study of transition metal complexes based on azo coumarin and thiosemicarbazone derivative
    Shobha S. Borhade
    Pravin T. Tryambake
    Journal of the Iranian Chemical Society, 2024, 21 : 719 - 730
  • [38] Synthesis, characterization and biological activity of copper complexes with pyridoxal thiosemicarbazone derivatives. X-ray crystal structure of three dimeric complexes
    Ferrari, MB
    Bisceglie, F
    Pelosi, G
    Tarasconi, P
    Albertini, R
    Dall'Aglio, PP
    Pinelli, S
    Bergamo, A
    Sava, G
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (02) : 301 - 312
  • [39] COPPER(I) AND COPPER(II) COMPLEXES OF TETRAMETHYLDIPHOSPHINEDISULFIDE .1. STRUCTURAL CHARACTERIZATION OF DINUCLEAR, MOLECULAR COMPLEX OF COPPER(I) CHLORIDE
    COTTON, FA
    FRENZ, BA
    HUNTER, DL
    MESTER, ZC
    INORGANICA CHIMICA ACTA, 1974, 11 (02) : 111 - 117
  • [40] Synthesis, characterization, and antitumor activity of azomethine derivative of triazole and its complexes with copper(I) and zinc(II) salts
    Shahriar Ghammamy
    Sajjad Sedaghat
    Russian Journal of General Chemistry, 2013, 83 : 722 - 725
12345