Metal complexes of Taxol precursor - 1. Synthesis, characterization and antitumor activity of the copper complex of 10-deacetylbaccatin thiosemicarbazone

被引：32
|
作者：
Murugkar, A
Padhye, S [1 ]
Guha-Roy, S
Wagh, U
机构：
[1] Univ Pune, Dept Chem, Pune 411007, Maharashtra, India
[2] Natl Ctr Cell Sci, Pune 411007, Maharashtra, India
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 1999年 / 2卷 / 11期
关键词：
10-DAB; Taxol; copper complexes; thiosemicarbazone;
D O I：
10.1016/S1387-7003(99)00152-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Incorporation of the thiosemicarbazone pharmacophore in the otherwise inactive baccatin nucleus, viz. 10-deacetylbaccatin (10-DAB), on complexation with copper renders a highly antiproliferative compound Cu-DABTSC. When tested on a human breast cancer cell line, MCF-7, it was observed that 10-DAB treated cells were growth arrested but viable whereas Cu-DABTSC was lethal to cells at comparative doses. (C) 1999 Elsevier Science S.A. All rights reserved.
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页码：545 / 548
页数：4
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