SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a

被引：54

作者：

Kim, Min-Ju ^{[4
,7
]}

Ahn, Kyungsook ^{[7
]}

Park, Seong-Hoon ^{[1
]}

Kang, Hong-Jun ^{[1
]}

Jang, Bong Geom ^{[7
]}

Oh, Soo-Jin ^{[1
]}

Oh, Sun-Mee ^{[1
]}

Jeong, Yu-Jin ^{[1
]}

Heo, Jee-In ^{[1
,5
]}

Suh, Jun-Gyo ^{[2
,5
]}

Lim, Soon Sung ^{[5
,6
]}

Ko, Yoon-Jung ^{[5
]}

Huh, Sung-Oh ^{[3
,5
]}

Kim, Sung Chan ^{[1
]}

Park, Jae-Bong ^{[1
]}

Kim, Jaebong ^{[1
]}

Kim, Jong-Il ^{[8
]}

Jo, Sangmee Ahn ^{[7
]}

Lee, Jae-Yong ^{[1
,5
]}

机构：

[1] Hallym Univ, Coll Med, Dept Biochem, Chunchon 200702, Gangwon Do, South Korea

[2] Hallym Univ, Coll Med, Dept Med Genet, Chunchon 200702, Gangwon Do, South Korea

[3] Hallym Univ, Coll Med, Dept Pharmacol, Chunchon 200702, Gangwon Do, South Korea

[4] Hallym Univ, Coll Med, Dept Anat & Neurobiol, Chunchon 200702, Gangwon Do, South Korea

[5] Hallym Univ, Coll Med, Inst Nat Med, Chunchon 200702, Gangwon Do, South Korea

[6] Hallym Univ, Dept Food Sci & Nutr, Chunchon 200702, Gangwon Do, South Korea

[7] Natl Inst Hlth, Ctr Biomed Sci, Div Brain Dis, Seoul 122701, South Korea

[8] Seoul Natl Univ, Coll Med, Dept Biochem, Seoul 100799, South Korea

来源：

FEBS LETTERS | 2009年 / 583卷 / 07期

关键词：

SIRT1; FOXO3a; Nicotinamide; Neuronal differentiation; Neuroblastoma; FORKHEAD TRANSCRIPTION FACTOR; HISTONE DEACETYLASE; NEURONAL DIFFERENTIATION; GROWTH-FACTOR; SUPPRESSION; INHIBITION; ACTIVATION; SH-SY5Y; INSULIN; DISEASE;

D O I：

10.1016/j.febslet.2009.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To examine the function of SIRT1 in neuronal differentiation, we employed all-trans retinoic acid (ATRA)-induced differentiation of neuroblastoma cells. Nicotinamide inhibited neurite outgrowth and tyrosine hydroxylase (TH) expression. Inhibition of PARP or histone deacetylase did not inhibit TH expression, showing the effect to be SIRT1 specific. Expression of FOXO3a and its target proteins were increased during the differentiation and reduced by nicotinamide. FOXO3a deacetylation was increased by ATRA and blocked by nicotinamide. SIRT1 and FOXO3a siRNA inhibited ATRA-induced up-regulation of TH and differentiation. Taken together, these results indicate that SIRT1 is involved in ATRA-induced differentiation of neuroblastoma cells via FOXO3a. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1183 / 1188

页数：6

共 50 条

[41] Effect of astaxanthin intervention on contrast induced acute kidney injury through the SIRT1/FOXO3a signal
Li Wenhua
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (16) : C179 - C179
[42] Astragaloside IV Inhibits the Pyroptosis in the Acute Kidney Injury through Targeting the SIRT1/FOXO3a Axis
Zha, Chengxi
Qi, Yaya
Xing, Fujun
Li, Jiansheng
CHEMICAL & PHARMACEUTICAL BULLETIN, 2024, 72 (10) : 923 - 931
[43] Dexmedetomidine Attenuates Ischemia and Reperfusion-Induced Cardiomyocyte Injury through SIRT1/FOXO3a Signaling
Ding, Han-Lin
Liu, Danyang
He, Jianfeng
Chen, Jiajia
Zhou, Dongcheng
Wang, Chan
Yang, Changming
Xia, Zhengyuan
Xia, Zhongyuan
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 385
[44] Investigation on the effect of ulinastatin on the apoptosis of vascular smooth muscle cells in rats with aortic dissection based on the Sirt1/FoxO3a pathway
Peng, Xiaopeng
Yuan, Haoyao
Chen, Guangtian
Guo, Yuliang
Liang, Qiuer
Chen, Qiming
Cao, Weidong
CELLULAR AND MOLECULAR BIOLOGY, 2023, 69 (13) : 96 - 101
[45] The role of NAMPT/SIRT1/FOXO3a pathway for the leukemic transformation in severe congenital neutropenia (CN) patients
Lippka, Y.
Kumar, Thakur B.
Lan, D.
Skokowa, J.
Welte, K.
KLINISCHE PADIATRIE, 2009, 221 (03): : 201 - 202
[46] Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
Sun, Wen
Qiao, Wanxin
Zhou, Bin
Hu, Zixuan
Yan, Quanquan
Wu, Jun
Wang, Rong
Zhang, Qian
Miao, Dengshun
METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 88 : 61 - 71
[47] Estradiol initiates the immune escape of non-small cell lung cancer cells via ERβ/SIRT1/FOXO3a/PD-L1 axis
Song, Shu
Tang, Haicheng
Quan, Wenqiang
Shang, Anquan
Ling, Chunhua
INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 107
[48] High-glucose treatment regulates biological functions of human umbilical vein endothelial cells via Sirt1/FOXO3 pathway
Chen, Yihui
Wang, Yan
Jiang, Yaping
Zhang, Xiaoyan
Sheng, Minjie
ANNALS OF TRANSLATIONAL MEDICINE, 2019, 7 (09)
[49] Resveratrol Regulates Sirt1 to Control B Cells Activation and Plasma B Cells Differentiation
Wang, Ting
Song, Xing
Luo, Xiaofang
Li, Mengtao
Zeng, Xiaofeng
ARTHRITIS & RHEUMATOLOGY, 2017, 69
[50] MiRNA-124-3p.1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1
Dong, Zhe-bin
Wu, Heng-miao
He, Yi-cheng
Huang, Zhong-ting
Weng, Yi-hui
Li, Hong
Liang, Chao
Yu, Wei-ming
Chen, Wei
CELL DEATH & DISEASE, 2022, 13 (01)

← 1 2 3 4 5 →